Tìm phát âm Basolateral Là Gì – Basolateral Membrane là phát minh vào content hiện tại của chúng tôi. Theo dõi bài viết để biết cụ thể nhé.
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Cell polarity refers to lớn the intrinsic asymmetry observed in cells, either in their shape, structure, or organization of cellular components. Most epithelial cells, migrating cells & developing cells require some form of cell polarity for their function. These cells receive sầu information about their surroundings via extracellular biochemical và mechanical cues và translate those information into polarity of the plasma membrane, its associated proteins và cytoskeletal organization. Once established, cell polarity is maintained by transcytosis, in which vesicles carry incorrectly-localized membrane proteins lớn the correct regions in the plasma membrane. In addition, tight junctions, which act as ‘fences’ against transmembrane diffusion, loông chồng the asymmetry in place. Therefore, thienmaonline.vnlogy plays an essential regulatory role in both the establishment & maintenance of cell polarity.
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Epithelial cells become polarized along the apical-basal axis. The apical membrane faces the lumen & is rich in PAR và Crumbs protein complexes. The basolateral membrane contains the Scribble complex và faces the extracellular matrix.
Epithelial cells establish an apical-basal polarity, which results from the differential distribution of phospholipids, protein complexes, và cytoskeletal components between the various plasma membrane domains, reflecting their specialized functions. The membrane facing the lumen or free surface is known as the apical membrane, while the membrane oriented away from the lumen, contacting theextracellular matrix, is known as the basal membrane và the sides of the cell contacting the neighboring cells khung the lateral membrane . The apico-basal polarization of epithelial cells is known to lớn be a pre-requisite for their fundamental biological roles. These include regulating the vectorial transport of ions across cell sheets during their barrier function as well as ensuring directionality during their secretory và absorptive functions .
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Developmental polarity is observed along three axes; anterior-posterior, dorsal-ventral & left-right. This polarity can be established by concentration gradients of secreted proteins, or by asymmetric organisation of cellular components, such as the cytoskeleton.
In other specialized cells such as immune cells & neurons, cell polarity enables the short-range và long-range transmission of various electrical và biochemical signals. For instance, A typical unipolar neuron has a highly distinctive sầu shape và structure, with one over adapted lớn receive sầu signals through highly branched dendrites. This signal is then transmitted down an axon, which can stretch the length of the body toàn thân. At the other kết thúc of the cell is the axon terminal, where the synapses are located. These synapses can release chemical neurotransmitters in order to propagate the signal or effect an action such asmuscle contraction.
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